Trichostatin A,histone deacetylase抑制剂(ab120850)
Key features and details
- Potent, selective histone deacetylase inhibitor
- CAS Number: 58880-19-6
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Streptomyces sp.
概述
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产品名称
Trichostatin A,histone deacetylase抑制剂 -
描述
Potent,selective histone deacetylase抑制剂 -
生物学描述
Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
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纯度
> 98% -
CAS编号
58880-19-6 -
化学结构
性能
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化学名称
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide -
分子量
302.37 -
分子式
C17H22N2O3 -
PubChem识别号
444732 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 10 mM and in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C -
来源
Streptomyces sp.
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研究领域
图片
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2D chemical structure image of ab120850, Trichostatin A, histone deacetylase inhibitor
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Trichostatin A inhibits histone deacetylases in NIH/3T3 cells.
Cells from logarithmic were incubated overnight with different concentrations of Trichostatin A (ab120850). Cell proteins were resolved by SDS-PAGE and probed with anti-acetylated histone antibodies.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120850 被引用在 3 文献中.
- Hu JX et al. Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury. Cell Death Dis 13:466 (2022). PubMed: 35585040
- Wang Y et al. Dexmedetomidine attenuates the toxicity of ß-amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5. Mol Med Rep 19:533-540 (2019). PubMed: 30483749
- Gehring KB et al. Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. Learn Mem 23:195-207 (2016). PubMed: 27084927