Anti-TXNRD1抗体(ab16840)
Key features and details
- Rabbit polyclonal to TXNRD1
- Suitable for: IP, ICC/IF, IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-TXNRD1抗体
参阅全部 TXNRD1 一抗 -
描述
兔多克隆抗体to TXNRD1 -
宿主
Rabbit -
经测试应用
适用于: IP, ICC/IF, IHC-P, WBmore details -
种属反应性
与反应: Mouse, Rat, Human
预测可用于: Horse, Cow, Chimpanzee, Ferret, Macaque monkey, Orangutan -
免疫原
Recombinant full length protein (Human).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.03% Sodium azide
Constituents: HEPES, 50% Glycerol, 0.87% Sodium chloride, 0.01% BSA -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab16840于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IP |
Use at an assay dependent concentration.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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|
WB | (2) |
1/2000. Predicted molecular weight: 55 kDa.
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说明 |
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IP
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
WB
1/2000. Predicted molecular weight: 55 kDa. |
靶标
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功能
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. -
组织特异性
Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. -
序列相似性
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Contains 1 glutaredoxin domain. -
结构域
The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays. -
翻译后修饰
The N-terminus of isoform 5 is blocked.
ISGylated. -
细胞定位
Cytoplasm and Cytoplasm. Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 282388 Cow
- Entrez Gene: 7296 Human
- Entrez Gene: 50493 Mouse
- Entrez Gene: 58819 Rat
- Omim: 601112 Human
- SwissProt: O62768 Cow
- SwissProt: Q16881 Human
- SwissProt: Q9JMH6 Mouse
see all -
别名
- cytoplasmic antibody
- Gene associated with retinoic and IFN-induced mortality 12 protein antibody
- Gene associated with retinoic and interferon-induced mortality 12 protein antibody
see all
图片
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ab16840 at 1/2000 dilution staining human TXNRD1 in HeLa, Jurkat, and 293T lysates by Western blot.
Lane 1: HeLa cell lysates.
Lane 2: 293T cell lysates.
Lane 3: Jurkat cell lysates.
ab16840 at 1/2000 dilution staining human TXNRD1 in HeLa, Jurkat, and 293T lysates by Western blot.
Lane 1: HeLa cell lysates.
Lane 2: 293T cell lysates.
Lane 3: Jurkat cell lysates.
数据表及文件
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SDS download
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Datasheet download
文献 (24)
ab16840 被引用在 24 文献中.
- Abdelhamid RF et al. piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis. Mol Neurobiol 59:1693-1705 (2022). PubMed: 35015250
- Wu DM et al. Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa. JCI Insight 6:N/A (2021). PubMed: 33491671
- Zarkada G et al. Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation. Dev Cell 56:2237-2251.e6 (2021). PubMed: 34273276
- Braunstein I et al. Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation. J Biol Chem 295:3590-3600 (2020). PubMed: 32041780
- Wu Z et al. Inflammatory response and oxidative stress attenuated by sulfiredoxin-1 in neuron-like cells depends on nuclear factor erythroid-2-related factor 2. Mol Med Rep 22:4734-4742 (2020). PubMed: 33173963