Anti-TNF Receptor II抗体(ab15563)
Key features and details
- Rabbit polyclonal to TNF Receptor II
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-TNF Receptor II抗体
参阅全部 TNF Receptor II 一抗 -
描述
兔多克隆抗体to TNF Receptor II -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide within Mouse TNF Receptor II aa 400 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: P25119 -
阳性对照
- IHC-P: Human thymus tissue.
-
常规说明
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab15563于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/50.
|
说明 |
---|
IHC-P
1/50. |
靶标
-
功能
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. -
序列相似性
Contains 4 TNFR-Cys repeats. -
翻译后修饰
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 7133 Human
- Entrez Gene: 21938 Mouse
- Omim: 191191 Human
- SwissProt: P20333 Human
- SwissProt: P25119 Mouse
- Unigene: 256278 Human
-
别名
- CD120b antibody
- p75 antibody
- p75 TNF receptor antibody
see all
图片
实验方案
数据表及文件
-
SDS download
-
Datasheet download
文献 (18)
ab15563 被引用在 18 文献中.
- Gouweleeuw L et al. Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice. Brain Behav Immun 93:156-171 (2021). PubMed: 33444731
- Tavares Pereira M et al. Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog. Front Vet Sci 7:625921 (2020). PubMed: 33634180
- Manetti M et al. TNF-a/TNF-R System May Represent a Crucial Mediator of Proliferative Synovitis in Hemophilia A. J Clin Med 8:N/A (2019). PubMed: 31261789
- Ping Z et al. TNF Receptor 1/2 Predict Heart Failure Risk in Type 2 Diabetes Mellitus Patients. Int Heart J 58:245-249 (2017). PubMed: 28367848
- Anantharam P et al. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci 1408:61-78 (2017). PubMed: 29239480