Anti-TNF Receptor I抗体(ab111119)
Key features and details
- Rabbit polyclonal to TNF Receptor I
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TNF Receptor I抗体
参阅全部 TNF Receptor I 一抗 -
描述
兔多克隆抗体to TNF Receptor I -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rat, Sheep, Rabbit, Hamster, Cow, Dog, Pig, Saccharomyces cerevisiae, Xenopus laevis, Drosophila melanogaster, Monkey -
免疫原
Synthetic peptide within Mouse TNF Receptor I. The exact sequence is proprietary.
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阳性对照
- IHC-P: Human Brain Cortex tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111119于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P | (2) |
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. -
疾病相关
Familial hibernian fever
Multiple sclerosis 5 -
序列相似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
结构域
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
翻译后修饰
The soluble form is produced from the membrane form by proteolytic processing. -
细胞定位
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 282527 Cow
- Entrez Gene: 7132 Human
- Entrez Gene: 397020 Pig
- Entrez Gene: 25625 Rat
- Omim: 191190 Human
- SwissProt: O19131 Cow
- SwissProt: P19438 Human
- SwissProt: P50555 Pig
see all -
别名
- CD120a antibody
- FPF antibody
- MGC19588 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab111119 被引用在 2 文献中.
- Xiao Z et al. A TNFR1-UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop. Cell Death Dis 13:885 (2022). PubMed: 36270982
- Ping Z et al. TNF Receptor 1/2 Predict Heart Failure Risk in Type 2 Diabetes Mellitus Patients. Int Heart J 58:245-249 (2017). PubMed: 28367848