TMPyP4 tosylate,Telomerase抑制剂(ab120793)
Key features and details
- Telomerase inhibitor. Binds and stabilizes DNA G-quadruplexes.
- CAS Number: 36951-72-1
- Purity: > 94%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
TMPyP4 tosylate,Telomerase抑制剂 -
描述
Telomerase抑制剂. Binds and stabilizes DNA G-quadruplexes. -
纯度
> 94% -
CAS编号
36951-72-1 -
化学结构
性能
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化学名称
5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate) -
分子量
1363.60 -
分子式
C72H66N8O12S4 -
存放说明
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120793于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Functional Studies |
Use at an assay dependent concentration.
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说明 |
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Functional Studies
Use at an assay dependent concentration. |
图片
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2D chemical structure image of ab120793, TMPyP4 tosylate, Telomerase inhibitor
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ab2893 staining ?H2A.X in weri cells treated with TMPyP4 tosylate (ab120793), by ICC/IF. Increase of ?H2A.X nuclear expression correlates with increased concentration of TMPyP4 tosylate, as described in literature.
The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab120793 (TMPyP4 tosylate ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2893 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120793 被引用在 2 文献中.
- Díaz-Cartagena DC et al. Label-Free Telomerase Activity Detection via Electrochemical Impedance Spectroscopy. ACS Omega 4:16724-16732 (2019). PubMed: 31646217
- Cid-Samper F et al. An Integrative Study of Protein-RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome. Cell Rep 25:3422-3434.e7 (2018). PubMed: 30566867