Anti-TMPRSS4抗体(ab82176)
Key features and details
- Goat polyclonal to TMPRSS4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TMPRSS4抗体
参阅全部 TMPRSS4 一抗 -
描述
山羊多克隆抗体to TMPRSS4 -
宿主
Goat -
特异性
ab82176 is expected to recognize both reported isoforms (NP_063947.1 and NP_001077416.1). -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide:
DSTRCNADDAYQGE
, corresponding to internal sequence amino acids 352-365 of Human TMPRSS4 (NP_063947.1) (or aa347-360 of NP_001077416.1). -
阳性对照
- WB: HEK-293 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab82176 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab82176于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa.
1 hour primary incubation is recommended for this product. |
说明 |
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WB
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa. 1 hour primary incubation is recommended for this product. |
靶标
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功能
Probable protease. Seems to be capable of activating ENaC. -
组织特异性
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. -
序列相似性
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 56649 Human
- Entrez Gene: 214523 Mouse
- Omim: 606565 Human
- SwissProt: Q9NRS4 Human
- SwissProt: Q8VCA5 Mouse
- Unigene: 161985 Human
- Unigene: 436756 Mouse
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别名
- UNQ776/PRO1570 antibody
- CAPH2 antibody
- Channel-activating protease 2 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (3)
ab82176 被引用在 3 文献中.
- Xiao H et al. Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial-mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT. Anim Cells Syst (Seoul) 25:211-218 (2021). PubMed: 34408809
- Fan X et al. The upregulation of TMPRSS4, partly ascribed to the downregulation of miR-125a-5p, promotes the growth of human lung adenocarcinoma via the NF-?B signaling pathway. Int J Oncol 53:148-158 (2018). PubMed: 29750426
- Li XM et al. Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer. Int J Mol Med 39:927-935 (2017). PubMed: 28259959