Anti-Shoc2 / Sur8抗体(ab106430)
Key features and details
- Rabbit polyclonal to Shoc2 / Sur8
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Shoc2 / Sur8抗体
参阅全部 Shoc2 / Sur8 一抗 -
描述
兔多克隆抗体to Shoc2 / Sur8 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
A 21 amino acid peptide near the N terminus of Human Shoc2/ Sur8 (NP_031399).
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阳性对照
- Jurkat cell lysate; Human spleen tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106430于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
靶标
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功能
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. -
疾病相关
Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) [MIM:607721]. NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair. -
序列相似性
Belongs to the SHOC2 family.
Contains 20 LRR (leucine-rich) repeats. -
细胞定位
Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation. - Information by UniProt
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数据库链接
- Entrez Gene: 8036 Human
- Omim: 602775 Human
- SwissProt: Q9UQ13 Human
- Unigene: 104315 Human
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别名
- KIAA0862 antibody
- Leucine-rich repeat protein SHOC-2 antibody
- Protein soc-2 homolog antibody
see all
图片
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Lane 1 : Anti-Shoc2 / Sur8 antibody (ab106430) at 1 µg/ml
Lane 2 : Anti-Shoc2 / Sur8 antibody (ab106430) at 2 µg/ml
All lanes : Jurkat cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 65 kDa -
ab106430, at 5 µg/ml, staining Shoc2 / Sur8 in paraffin embedded Human spleen tissue by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab106430 被引用在 3 文献中.
- McBrearty N et al. Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice. Neoplasia 23:529-538 (2021). PubMed: 33945993
- Xie CM et al. The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. Cell Rep 26:3037-3050.e4 (2019). PubMed: 30865892
- Yen I et al. Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors. Cancer Cell 34:611-625.e7 (2018). PubMed: 30300582