Anti-SMAD9抗体(ab96698)
Key features and details
- Rabbit polyclonal to SMAD9
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SMAD9抗体
参阅全部 SMAD9 一抗 -
描述
兔多克隆抗体to SMAD9 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Zebrafish -
免疫原
Recombinant protein fragment, corresponding to a region within amino acids 166 and 353 of Human SMAD9 (AAH11559).
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阳性对照
- NT2D1 whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96698于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 49 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 49 kDa. |
靶标
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功能
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). -
组织特异性
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney. -
疾病相关
Pulmonary hypertension, primary, 2 -
序列相似性
Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain. -
翻译后修饰
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. -
细胞定位
Cytoplasm. Nucleus. In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. - Information by UniProt
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数据库链接
- Entrez Gene: 4093 Human
- Entrez Gene: 55994 Mouse
- Entrez Gene: 85435 Rat
- Omim: 603295 Human
- SwissProt: O15198 Human
- SwissProt: Q9JIW5 Mouse
- SwissProt: O54835 Rat
- Unigene: 123119 Human
see all -
别名
- MAD homolog 9 antibody
- Madh6 antibody
- Mothers against decapentaplegic antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab96698 被引用在 3 文献中.
- Gao L et al. Reduction of miR-744 delivered by NSCLC cell-derived extracellular vesicles upregulates SUV39H1 to promote NSCLC progression via activation of the Smad9/BMP9 axis. J Transl Med 19:37 (2021). PubMed: 33472665
- McDonald GLK et al. Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. Biomolecules 11:N/A (2021). PubMed: 33668680
- Gregson CL et al. A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis. J Bone Miner Res 35:92-105 (2020). PubMed: 31525280