Anti-SLC40A1抗体(ab78066)
Key features and details
- Rabbit polyclonal to SLC40A1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SLC40A1抗体
参阅全部 SLC40A1 一抗 -
描述
兔多克隆抗体to SLC40A1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rat -
免疫原
Synthetic peptide corresponding to Human SLC40A1 (N terminal).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab78066于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P | (2) |
Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). -
组织特异性
Expressed in placenta, intestine, muscle and spleen. -
疾病相关
Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. -
序列相似性
Belongs to the SLC40A transporter family. -
细胞定位
Cell membrane. Localized to the basolateral membrane of polarized epithelial cells. - Information by UniProt
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数据库链接
- Entrez Gene: 30061 Human
- Entrez Gene: 170840 Rat
- Omim: 604653 Human
- SwissProt: Q9NP59 Human
- SwissProt: Q923U9 Rat
- Unigene: 643005 Human
- Unigene: 15324 Rat
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别名
- Ferroportin 1 antibody
- Ferroportin antibody
- Ferroportin-1 antibody
see all
图片
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ab78066, at 20µg/ml, staining SLC40A1 in human skeletal muscle by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
A heat induced antigen retrieval step was performed using pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. -
Immunohistochemical staining of paraffin embedded, formalin fixed, kidney renal tubular epithelium using ab78066 at 20 µg/mL.
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Negative control - immunohistochemical staining of paraffin embedded, formalin fixed, breast epithelium using ab78066 at 20 µg/mL.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (23)
ab78066 被引用在 23 文献中.
- Zhang G et al. 1-2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis. J Orthop Translat 38:126-140 (2023). PubMed: 36381248
- Zheng J et al. Norcantharidin down-regulates iron contents in the liver and spleen of lipopolysaccharide-treated mice. Redox Rep 27:119-127 (2022). PubMed: 35735222
- Pei Z et al. Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model. Redox Biol 57:102509 (2022). PubMed: 36302319
- Li D et al. Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis. Br J Pharmacol 178:1182-1199 (2021). PubMed: 33450067
- Wu A et al. Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis. Redox Biol 46:102131 (2021). PubMed: 34530349