Anti-SLC16A3/MCT 4抗体(ab74109)
Key features and details
- Rabbit polyclonal to SLC16A3/MCT 4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SLC16A3/MCT 4抗体
参阅全部 SLC16A3/MCT 4 一抗 -
描述
兔多克隆抗体to SLC16A3/MCT 4 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Extracts from LOVO cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab74109于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 49 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 49 kDa. |
靶标
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功能
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. -
组织特异性
Highly expressed in skeletal muscle. -
序列相似性
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 9123 Human
- Entrez Gene: 80879 Mouse
- Entrez Gene: 80878 Rat
- Omim: 603877 Human
- SwissProt: O15427 Human
- SwissProt: P57787 Mouse
- SwissProt: O35910 Rat
- Unigene: 500761 Human
see all -
形式
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 and MCT2, are characterized by 12 predicted transmembrane domains. -
别名
- MCT 4 antibody
- MCT3 antibody
- MCT4 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (10)
ab74109 被引用在 10 文献中.
- Kieran NW et al. MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes. J Neuroinflammation 19:10 (2022). PubMed: 34991629
- Cluntun AA et al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab 33:629-648.e10 (2021). PubMed: 33333007
- Yang S et al. LINC00035 Transcriptional Regulation of SLC16A3 via CEBPB Affects Glycolysis and Cell Apoptosis in Ovarian Cancer. Evid Based Complement Alternat Med 2021:5802082 (2021). PubMed: 34671407
- Zhao D et al. Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast. Poult Sci 99:11-20 (2020). PubMed: 32416791
- Sun K et al. Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling. EBioMedicine 41:370-383 (2019). PubMed: 30799198
- Brosel S et al. An auditory brainstem nucleus as a model system for neuronal metabolic demands. Eur J Neurosci 47:222-235 (2018). PubMed: 29205598
- Chatel B et al. Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice. J Appl Physiol (1985) 122:1362-1369 (2017). PubMed: 28280108
- England EM et al. Chronic activation of AMP-activated protein kinase increases monocarboxylate transporter 2 and 4 expression in skeletal muscle. J Anim Sci 95:3552-3562 (2017). PubMed: 28805903
- Zawislak A et al. Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner. Oncotarget 8:106625-106638 (2017). PubMed: 29290976
- Ghorbel MT et al. Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury. BMC Genomics 15:916 (2014). PubMed: 25331815