Anti-SEC63抗体(ab68550)
Key features and details
- Mouse polyclonal to SEC63
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SEC63抗体
参阅全部 SEC63 一抗 -
描述
小鼠多克隆抗体to SEC63 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein within Human SEC63. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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阳性对照
- Human pancreas lysate, SEC63 transfected 293T cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.40
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab68550于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 88 kDa (predicted molecular weight: 88 kDa).
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 88 kDa (predicted molecular weight: 88 kDa). |
靶标
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相关性
SEC63 and SEC62 proteins are found to be associated with the ribosome-free SEC61 complex, which is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Mutations in SEC63 cause autosomal dominant polycystic liver disease. -
细胞定位
Endoplasmic reticulum membrane; Multi pass membrane protein. -
数据库链接
- Entrez Gene: 11231 Human
- Omim: 608648 Human
- SwissProt: Q9UGP8 Human
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别名
- ERdj2 antibody
- PRO2507 antibody
- SEC 63 antibody
see all
图片
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Anti-SEC63 antibody (ab68550) at 1/500 dilution + Human pancreas lysate at 50 µg
Secondary
Goat Anti-Mouse IgG (H&L) at 1/2500 dilution
Predicted band size: 88 kDa
Observed band size: 88 kDa -
All lanes : Anti-SEC63 antibody (ab68550) at 1/500 dilution
Lane 1 : SEC63 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L) at 1/2500 dilution
Predicted band size: 88 kDa
Observed band size: 88 kDa
数据表及文件
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Datasheet download
文献 (1)
ab68550 被引用在 1 文献中.
- Singh S et al. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC. Biochemistry 59:2299-2311 (2020). PubMed: 32462874