Anti-SCN11A抗体(ab65160)
Key features and details
- Rabbit polyclonal to SCN11A
- Suitable for: IHC-Fr, IHC-P, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SCN11A抗体
参阅全部 SCN11A 一抗 -
描述
兔多克隆抗体to SCN11A -
宿主
Rabbit -
经测试应用
适用于: IHC-Fr, IHC-P, ICC/IF, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide derived from N terminal squence of human SCN11A.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab65160于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-Fr | ||
IHC-P | ||
ICC/IF | ||
WB |
说明 |
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IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
WB: 1/1000 - 1/5000. Predicted molecular weight: 205 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. -
组织特异性
Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. -
疾病相关
Neuropathy, hereditary sensory and autonomic, 7
Episodic pain syndrome, familial, 3 -
序列相似性
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. -
结构域
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. -
翻译后修饰
Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 11280 Human
- Omim: 604385 Human
- SwissProt: Q9UI33 Human
- Unigene: 591657 Human
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别名
- hNaN antibody
- NaN antibody
- NAV1.9 antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (1)
ab65160 被引用在 1 文献中.
- Pinto FM et al. Molecular and functional characterization of voltage-gated sodium channels in human sperm. Reprod Biol Endocrinol 7:71 (2009). ICC/IF ; Human . PubMed: 19607678