重组人Profilin 1蛋白(ab87760)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
描述
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产品名称
重组人Profilin 1蛋白
参阅全部 Profilin 1 蛋白酶 -
纯度
> 95 % SDS-PAGE.
ab87760 is purified using conventional chromatography techniques. -
表达系统
Escherichia coli -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab87760 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Liquid -
补充说明
Endotoxin level: < 1.0 EU per 1 µg of protein (determined by LAL method). -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.316% Tris HCl, 10% Glycerol
常规信息
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别名
- Actin binding protein
- ALS18
- Epididymis tissue protein Li 184a
see all -
功能
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. -
序列相似性
Belongs to the profilin family. -
细胞定位
Cytoplasm > cytoskeleton. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab87760 被引用在 6 文献中.
- Ramírez de Mingo D et al. Conformational dynamics in the disordered region of human CPEB3 linked to memory consolidation. BMC Biol 20:129 (2022). PubMed: 35658951
- Allen A et al. Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells. J Biol Chem 295:15636-15649 (2020). PubMed: 32883810
- George L et al. Profilin-1 is dysregulated in endometroid (type I) endometrial cancer promoting cell proliferation and inhibiting pro-inflammatory cytokine production. Biochem Biophys Res Commun 531:459-464 (2020). PubMed: 32800551
- Menkhorst EM et al. Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5. Sci Rep 7:8690 (2017). PubMed: 28821715
- Zienkiewicz A et al. Chip-based capillary electrophoresis profiling of olive pollen extracts used for allergy diagnosis and immunotherapy. Electrophoresis 35:2681-5 (2014). PubMed: 24888349
- Caglayan E et al. Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One 5:e13608 (2010). PubMed: 21049052