重组人Nrf2蛋白(ab114160)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: WB, ELISA, SDS-PAGE
描述
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产品名称
重组人Nrf2蛋白
参阅全部 Nrf2 蛋白酶 -
表达系统
Wheat germ -
Accession
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蛋白长度
Protein fragment -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
FAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVA -
预测分子量
37 kDa including tags -
氨基酸
71 to 170 -
标签
GST tag N-Terminus
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技术指标
Our Abpromise guarantee covers the use of ab114160 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Western blot
ELISA
SDS-PAGE
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8
Constituents: 0.3% Glutathione, 0.79% Tris HCl
常规信息
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别名
- erythroid derived 2
- HEBP1
- like 2
see all -
功能
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. -
组织特异性
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. -
序列相似性
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain. -
结构域
Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus. -
翻译后修饰
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. -
细胞定位
Cytoplasm > cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab114160 尚未被引用在任何文献中。