Q-DEVD-OPh,caspase-3抑制剂(ab142037)
Key features and details
- Potent, irreversible, cell-permeable caspase-3 inhibitor
- CAS Number:
- Purity: > 90%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Q-DEVD-OPh,caspase-3抑制剂 -
描述
Potent,irreversible,cell-permeable caspase-3抑制剂 -
生物学描述
Potent, irreversible, cell-permeable caspase-3 inhibitor -
纯度
> 90% -
常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 1175 Caspase-3 Inhibitor Q-DEVD-OPh. 1175-5 is the same size as the 5 mg size of ab142037.
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化学结构
性能
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分子量
799.77 -
分子式
C38H43F2N5O12 -
序列
DEVD (Modifications: N-terminal quinolyl; C-terminal OPh; Asp-1 = Asp(OMe); Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem识别号
44135278 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)C2=NC3=CC=CC=C3C=C2 -
来源
Synthetic
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研究领域
相关产品
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Related Products
图片
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2D chemical structure image of ab142037, Q-DEVD-OPh, caspase-3 inhibitor
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Titration of the Caspase 3 specific inhibitor Q-DEVD-OPh (ab142037) (duplicates; +/- SD).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab142037 被引用在 1 文献中.
- Zhou XY et al. Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes. Cell Death Dis 8:e2618 (2017). PubMed: 28206988