Anti-PNN/DRSP抗体(ab108485)
Key features and details
- Rabbit polyclonal to PNN/DRSP
- Suitable for: IP, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PNN/DRSP抗体
参阅全部 PNN/DRSP 一抗 -
描述
兔多克隆抗体to PNN/DRSP -
宿主
Rabbit -
经测试应用
适用于: IP, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment (His-tag) corresponding to PNN/DRSP aa 1-132.
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阳性对照
- U2OS cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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纯度
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab108485于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IP |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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说明 |
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IP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. -
组织特异性
Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. -
序列相似性
Belongs to the pinin family. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein. - Information by UniProt
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数据库链接
- Entrez Gene: 5411 Human
- Omim: 603154 Human
- SwissProt: Q9H307 Human
- Unigene: 409965 Human
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别名
- 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
- Desmosome-associated protein antibody
- Domain-rich serine protein antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab108485 被引用在 3 文献中.
- Qiao K et al. Pinin Induces Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating m6A Modification. J Oncol 2021:7529164 (2021). PubMed: 34917148
- Carvalho T et al. Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay. J Cell Sci 130:1519-1531 (2017). PubMed: 28302904
- Bracken CP et al. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res 68:7621-8 (2008). PubMed: 18794151