Anti-PR3抗体[WGM2] (ab91181)
Key features and details
- Mouse monoclonal [WGM2] to PR3
- Suitable for: Inhibition Assay, ELISA, IHC-Fr, IHC-P, Flow Cyt, WB, Functional Studies
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
Anti-PR3抗体[WGM2]
参阅全部 PR3 一抗 -
描述
小鼠单克隆抗体[WGM2] to PR3 -
宿主
Mouse -
经测试应用
适用于: Inhibition Assay, ELISA, IHC-Fr, IHC-P, Flow Cyt, WB, Functional Studiesmore details -
种属反应性
与反应: Human -
免疫原
Full length protein. This information is proprietary to Abcam and/or its suppliers.
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常规说明
ab91181 blocks the PR3 activity and partially inhibits the binding of Human PR3-ANCA to PR3; it can be used in immuno assays, for inhibition of biological PR3 activity and induction of monocytes and neutrophils activation.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
0.2 µm filtered antibody solution -
Primary antibody说明
ab91181 blocks the PR3 activity and partially inhibits the binding of Human PR3-ANCA to PR3; it can be used in immuno assays, for inhibition of biological PR3 activity and induction of monocytes and neutrophils activation. -
克隆
单克隆 -
克隆编号
WGM2 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab91181于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Inhibition Assay |
Use at an assay dependent concentration.
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ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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WB |
Use at an assay dependent concentration.
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Functional Studies |
Use at an assay dependent concentration.
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说明 |
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Inhibition Assay
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. |
靶标
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功能
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. -
序列相似性
Belongs to the peptidase S1 family. Elastase subfamily.
Contains 1 peptidase S1 domain. - Information by UniProt
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数据库链接
- Entrez Gene: 5657 Human
- Omim: 177020 Human
- SwissProt: P24158 Human
- Unigene: 928 Human
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别名
- ACPA antibody
- AGP 7 antibody
- AGP7 antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (13)
ab91181 被引用在 13 文献中.
- Jiang ZZ et al. Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells. Oncoimmunology 11:2052418 (2022). PubMed: 35309732
- Hao J et al. Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils. BMC Immunol 20:22 (2019). PubMed: 31248381
- Kasperkiewicz P et al. Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils. J Am Chem Soc 139:10115-10125 (2017). PubMed: 28672107
- Singh N et al. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech 9:885-97 (2016). Human . PubMed: 27483354
- Murakami M et al. Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS One 9:e110677 (2014). PubMed: 25330301