Anti-OATP1B1抗体[MDQ] (ab15442)
Key features and details
- Mouse monoclonal [MDQ] to OATP1B1
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-OATP1B1抗体[MDQ]
参阅全部 OATP1B1 一抗 -
描述
小鼠单克隆抗体[MDQ] to OATP1B1 -
宿主
Mouse -
特异性
Ab15442 will also cross react with OATP8. -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Human
不与反应: Mouse, Rat, Dog -
免疫原
Synthetic peptide corresponding to Human OATP1B1 aa 1-23.
Sequence:MDQNQHLNKTAEAQPSENKKTRY
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阳性对照
- Human liver tissue slides.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
MDQ -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab15442于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ICC/IF |
1/20.
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说明 |
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ICC/IF
1/20. |
靶标
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功能
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver. -
组织特异性
Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. -
序列相似性
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain. -
细胞定位
Basolateral cell membrane. Detected in basolateral membranes of hepatocytes. - Information by UniProt
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数据库链接
- Entrez Gene: 10599 Human
- Omim: 604843 Human
- SwissProt: Q9Y6L6 Human
- Unigene: 449738 Human
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别名
- Liver-specific organic anion transporter 1 antibody
- LST-1 antibody
- LST1 antibody
see all
图片
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Immunocytochemistry/Immunofluorescence analysis of HepG2 cells labeling OATP1B1 (green) with ab15542 at 1/20. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue). Cells were fixed with formaldehyde and incubated with the primary antibody overnight at 4°C. A DyLight 488-conjugated secondary antibody was used. 60X magnification. Right - negative control.
实验方案
数据表及文件
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Datasheet download
文献 (3)
ab15442 被引用在 3 文献中.
- Imada S et al. Central bisectionectomy for hepatocellular carcinoma in a patient with indocyanine green excretory defect associated with reduced expression of the liver transporter. Surg Case Rep 2:89 (2016). PubMed: 27589984
- Peng JF et al. Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid. Biomol Ther (Seoul) 23:400-6 (2015). WB . PubMed: 26336578
- Sticova E et al. Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis. Int J Clin Exp Pathol 8:5252-62 (2015). PubMed: 26191226