Anti-NR0B2抗体(ab96605)
Key features and details
- Rabbit polyclonal to NR0B2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-NR0B2抗体
参阅全部 NR0B2 一抗 -
描述
兔多克隆抗体to NR0B2 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment, corresponding to a region within the internal sequence amino acids 64-246 of Human NR0B2.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96605于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 28 kDa.
|
|
IHC-P |
1/100 - 1/250.
|
说明 |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 28 kDa. |
IHC-P
1/100 - 1/250. |
靶标
-
功能
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. -
组织特异性
Liver. Low levels of expression were detected in heart and pancreas. -
疾病相关
Obesity -
序列相似性
Belongs to the nuclear hormone receptor family. NR0 subfamily. -
翻译后修饰
Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. -
细胞定位
Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus. - Information by UniProt
-
数据库链接
- Entrez Gene: 8431 Human
- Omim: 604630 Human
- SwissProt: Q15466 Human
- Unigene: 427055 Human
-
别名
- NR0B2 antibody
- NR0B2_HUMAN antibody
- Nr0b2a antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (3)
ab96605 被引用在 3 文献中.
- Chen SW et al. Dietary Nano-ZnO Is Absorbed via Endocytosis and ZIP Pathways, Upregulates Lipogenesis, and Induces Lipotoxicity in the Intestine of Yellow Catfish. Int J Mol Sci 22:N/A (2021). PubMed: 34769475
- Gallo-Ebert C et al. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 293:5956-5974 (2018). PubMed: 29491146
- Prestin K et al. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells. Onco Targets Ther 9:4867-78 (2016). WB ; Human . PubMed: 27540300