Anti-NOXO1抗体(ab97788)
Key features and details
- Rabbit polyclonal to NOXO1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-NOXO1抗体 -
描述
兔多克隆抗体to NOXO1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide, corresponding to a region within amino acids 307-370 of Human NOXO1 (NP_653204)
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阳性对照
- HCT116 whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab97788于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Predicted molecular weight: 41 kDa.
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说明 |
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WB
1/1000. Predicted molecular weight: 41 kDa. |
靶标
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功能
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. -
组织特异性
Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. -
序列相似性
Contains 1 PX (phox homology) domain.
Contains 2 SH3 domains. -
发展阶段
Isoform 3 is expressed in fetal liver. -
结构域
The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region. -
细胞定位
Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner. - Information by UniProt
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数据库链接
- Entrez Gene: 124056 Human
- Omim: 611256 Human
- SwissProt: Q8NFA2 Human
- Unigene: 191762 Human
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别名
- NADPH oxidase organizer 1 antibody
- NADPH oxidase regulatory protein antibody
- Nox organizer 1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab97788 尚未被引用在任何文献中。