NG-Monomethyl-L-arginine,monoacetate salt (L-NMMA),NOS抑制剂(ab120137)
Key features and details
- NOS inhibitor
- CAS Number: 53308-83-1
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
NG-Monomethyl-L-arginine,monoacetate salt (L-NMMA),NOS抑制剂 -
描述
NOS抑制剂 -
别名
- L-NMMA
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生物学描述
Cell-permeable competitive NOS inhibitor. (Ki values are 700 nM, 3.9 µM and 650 nM for eNOS, iNOS and nNOS, respectively).
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CAS编号
53308-83-1 -
化学结构
性能
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化学名称
NG-Methyl-L-arginine acetate -
分子量
248.28 -
分子式
C7H16N4O2.CH3CO2H -
PubChem识别号
135242 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N[C@@H](CCCNC(=N)NC)C(=O)O.CC(=O)O -
来源
Synthetic
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研究领域
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (8)
ab120137 被引用在 8 文献中.
- Wong NF & Xu-Friedman MA Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses. J Neurosci 42:6211-6220 (2022). PubMed: 35790402
- Ebner J et al. Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Cav1.2 channel modulation under basal conditions. Pflugers Arch 472:61-74 (2020). PubMed: 31822999
- Roselló-Busquets C et al. Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide. Front Mol Neurosci 13:56 (2020). PubMed: 32317932
- Devarakonda CV et al. CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions. Atherosclerosis 287:70-80 (2019). PubMed: 31229835
- Lim SY et al. A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation. Biomol Ther (Seoul) 25:519-527 (2017). PubMed: 28554197
- Lood C et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med N/A:N/A (2016). PubMed: 26779811
- Liu G et al. Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells. J Immunol 192:3068-79 (2014). PubMed: 24567529
- Liu X et al. Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism. J Physiol 591:3309-24 (2013). PubMed: 23613534