N-Desmethyl clozapine (Normethylclozapine),Clozapine metabolite. M1激动剂. D2/D3激动剂. (ab120026)
Key features and details
- Clozapine metabolite. M1 agonist. D2/D3 agonist.
- CAS Number: 6104-71-8
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
N-Desmethyl clozapine (Normethylclozapine),Clozapine metabolite. M1激动剂. D2/D3激动剂. -
描述
Clozapine metabolite. M1激动剂. D2/D3激动剂. -
别名
- Normethylclozapine
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生物学描述
Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.
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CAS编号
6104-71-8 -
化学结构
性能
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化学名称
8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine -
分子量
312.80 -
分子式
C17H17ClN4 -
PubChem识别号
2820 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc2Nc4ccccc4C(=Nc2c1)N3CCNCC3 -
来源
Synthetic
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研究领域
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
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