重组Anti-Mesothelin抗体[SP74] - C-terminal,prediluted (ab228144)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP74] to Mesothelin - C-terminal, prediluted
- Suitable for: IHC-P
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-Mesothelin抗体[SP74] - C-terminal,prediluted
参阅全部 Mesothelin 一抗 -
描述
兔单克隆抗体[SP74] to Mesothelin - C-terminal,prediluted -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Pig -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- IHC-P: Human mesothelioma and ovarian adenocarcinoma tissue.
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常规说明
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Do Not Freeze. -
存储溶液
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: Tris buffered saline, 1% BSA -
Concentration information loading...
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纯度
Protein A/G purified -
纯化说明
Purified from TCS by protein A/G. -
克隆
单克隆 -
克隆编号
SP74 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
- Anti-Mesothelin antibody [SP74] - BSA and Azide free (ab236217)
- Alexa Fluor® 488 Anti-Mesothelin antibody [SP74] (ab311060)
- Alexa Fluor® 647 Anti-Mesothelin antibody [SP74] (ab311184)
- Alexa Fluor® 594 Anti-Mesothelin antibody [SP74] (ab311842)
- Alexa Fluor® 568 Anti-Mesothelin antibody [SP74] (ab313125)
- Alexa Fluor® 555 Anti-Mesothelin antibody [SP74] (ab313317)
- Anti-Mesothelin antibody [SP74] (ab93620)
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab228144于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/1. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Pre-diluted / ready to use. |
说明 |
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IHC-P
1/1. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Pre-diluted / ready to use. |
靶标
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功能
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. -
组织特异性
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). -
疾病相关
Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. -
序列相似性
Belongs to the mesothelin family. -
翻译后修饰
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. -
细胞定位
Secreted and Cell membrane. Golgi apparatus. - Information by UniProt
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数据库链接
- Entrez Gene: 10232 Human
- Entrez Gene: 100524016 Pig
- Omim: 601051 Human
- SwissProt: Q13421 Human
- Unigene: 408488 Human
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别名
- CAK 1 antibody
- CAK1 antibody
- CAK1 antigen antibody
see all
图片
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Formalin-fixed, paraffin-embedded human mesothelioma tissue stained for Mesothelin using ab228144 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human mesothelioma tissue stained for Mesothelin using ab228144 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human ovarian adenocarcinoma tissue stained for Mesothelin using ab228144 in immunohistochemical analysis.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab228144 尚未被引用在任何文献中。