Anti-Meprin beta抗体(ab42743)
Key features and details
- Rabbit polyclonal to Meprin beta
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Meprin beta抗体
参阅全部 Meprin beta 一抗 -
描述
兔多克隆抗体to Meprin beta -
宿主
Rabbit -
特异性
Meprin beta antibody Math Domain recognizes meprin beta but not alpha subunits. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: 50% Glycerol -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Peptide-affinity purified. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab42743于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Predicted molecular weight: 84 kDa.
1/1000 for using colorimetric substrates such as BCIP/NBT. WB: 1/5000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. Dilution optimised using Chromogenic detection. |
说明 |
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WB
1/1000. Predicted molecular weight: 84 kDa. 1/1000 for using colorimetric substrates such as BCIP/NBT. WB: 1/5000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. Dilution optimised using Chromogenic detection. |
靶标
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功能
Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. -
组织特异性
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells. -
序列相似性
Belongs to the peptidase M12A family.
Contains 1 EGF-like domain.
Contains 1 MAM domain.
Contains 1 MATH domain. -
翻译后修饰
N-glycosylated; contains high mannose and/or complex biantennary structures.
O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.
Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues. -
细胞定位
Cell membrane. Secreted. Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. - Information by UniProt
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数据库链接
- Entrez Gene: 4225 Human
- Omim: 600389 Human
- SwissProt: Q16820 Human
- Unigene: 194777 Human
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别名
- Endopeptidase 2 antibody
- Endopeptidase-2 antibody
- kinase splitting membranal proteinase antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab42743 被引用在 2 文献中.
- Gao R et al. Meprin-a (Mep1A) enhances TNF-a secretion by mast cells and aggravates abdominal aortic aneurysms. Br J Pharmacol 177:2872-2885 (2020). PubMed: 32072633
- Livingston MJ et al. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy 12:976-98 (2016). PubMed: 27123926