Anti-Mannan Binding Lectin/MBL抗体[1E2] (ab23458)
Key features and details
- Mouse monoclonal [1E2] to Mannan Binding Lectin/MBL
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Mannan Binding Lectin/MBL抗体[1E2]
参阅全部 Mannan Binding Lectin/MBL 一抗 -
描述
小鼠单克隆抗体[1E2] to Mannan Binding Lectin/MBL -
宿主
Mouse -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Human -
免疫原
Full length protein corresponding to Human Mannan Binding Lectin/MBL.
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常规说明
ab23458 reacts with human MBL both in its poltmeric conforation and as a single subunit of moleculat mass 26 kDa. Can be applied for quantitative measurement of MBL in plasma or serum.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
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纯度
Protein G purified -
Primary antibody说明
Ab 23458 reacts with human MBL both in its poltmeric conforation and as a single subunit of moleculat mass 26 kDa. Can be applied for quantitative measurement of MBL in plasma or serum. -
克隆
单克隆 -
克隆编号
1E2 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23458于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ELISA |
1/10000.
|
|
WB |
Use at an assay dependent dilution. Predicted molecular weight: 26 kDa.
|
说明 |
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ELISA
1/10000. |
WB
Use at an assay dependent dilution. Predicted molecular weight: 26 kDa. |
靶标
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功能
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. -
组织特异性
Plasma protein produced mainly in the liver. -
疾病相关
Note=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections. -
序列相似性
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 4153 Human
- Omim: 154545 Human
- SwissProt: P11226 Human
- Unigene: 499674 Human
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别名
- COLEC 1 antibody
- COLEC1 antibody
- Collectin-1 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab23458 被引用在 4 文献中.
- Liu C et al. Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1. Stem Cells Int 2021:1530445 (2021). PubMed: 34691188
- Harboe M et al. Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions. Clin Exp Immunol 144:512-20 (2006). PubMed: 16734621
- Downing I et al. Immature dendritic cells possess a sugar-sensitive receptor for human mannan-binding lectin. Immunology 109:360-4 (2003). PubMed: 12807481
- Sund S et al. Complement activation in early protocol kidney graft biopsies after living-donor transplantation. Transplantation 75:1204-13 (2003). PubMed: 12717204