Anti-MVP抗体[1032] - BSA and Azide free (ab213122)
Key features and details
- Mouse monoclonal [1032] to MVP - BSA and Azide free
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-MVP抗体[1032] - BSA and Azide free
参阅全部 MVP 一抗 -
描述
小鼠单克隆抗体[1032] to MVP - BSA and Azide free -
宿主
Mouse -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human MVP. (Proteins precipitated from Human breast cancer MCF7 cells).
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阳性对照
- Human testicular carcinoma and breast carcinoma tissues; MCF7 and HeLa cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Constituent: 100% PBS -
无载体
是 -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
ab213122 was purified from bioreactor concentrate by Protein A/G. -
克隆
单克隆 -
克隆编号
1032 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab213122于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
(Primary incubation for 30 minutes at RT). |
说明 |
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IHC-P
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. (Primary incubation for 30 minutes at RT). |
靶标
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功能
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. -
组织特异性
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. -
序列相似性
Contains 9 MVP (vault) repeats. -
结构域
MVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4. -
翻译后修饰
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11. -
细胞定位
Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment. - Information by UniProt
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数据库链接
- Entrez Gene: 9961 Human
- Omim: 605088 Human
- SwissProt: Q14764 Human
- Unigene: 632177 Human
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别名
- LRP antibody
- Lung resistance related protein antibody
- Lung resistance-related protein antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab213122 尚未被引用在任何文献中。