Anti-MOX1/MEOX1抗体(ab105349)
Key features and details
- Rabbit polyclonal to MOX1/MEOX1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-MOX1/MEOX1抗体
参阅全部 MOX1/MEOX1 一抗 -
描述
兔多克隆抗体to MOX1/MEOX1 -
宿主
Rabbit -
特异性
Predicted to not crossreact with MOX2. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human MOX1/MEOX1 (internal sequence).
Database link: P50221 -
阳性对照
- WB: Human liver tissue lysate.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105349于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 28 kDa.
|
说明 |
---|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 28 kDa. |
靶标
-
功能
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. -
疾病相关
Klippel-Feil syndrome 2, autosomal recessive -
序列相似性
Contains 1 homeobox DNA-binding domain. -
细胞定位
Nucleus. Cytoplasm. Localizes predominantly in the nucleus. - Information by UniProt
-
数据库链接
- Entrez Gene: 4222 Human
- Omim: 600147 Human
- SwissProt: P50221 Human
- Unigene: 438 Human
-
别名
- Homeobox protein MOX-1 antibody
- MEOX1 antibody
- MEOX1_HUMAN antibody
see all
图片
实验方案
数据表及文件
-
SDS download
-
Datasheet download
文献 (3)
ab105349 被引用在 3 文献中.
- Wang W et al. PPARa Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1. Front Pharmacol 11:528267 (2020). PubMed: 33132907
- Wu B et al. Data on the involvement of Meox1 in balloon-injury-induced neointima formation of rats. Data Brief 16:266-270 (2018). PubMed: 29204471
- Dong K et al. Mesenchyme homeobox 1 mediates transforming growth factor-ß (TGF-ß)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors. J Biol Chem 293:8712-8719 (2018). PubMed: 29678882