Anti-MORC3抗体(ab76813)
Key features and details
- Mouse polyclonal to MORC3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-MORC3抗体
参阅全部 MORC3 一抗 -
描述
小鼠多克隆抗体to MORC3 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein within Human MORC3. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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阳性对照
- HeLa whole cell lysate (ab150035).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab76813于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 107 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 107 kDa. |
靶标
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功能
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). -
组织特异性
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney. -
序列相似性
Contains 1 CW-type zinc finger. -
翻译后修饰
Sumoylation is involved in interaction with PML and localization to PML nuclear bodies. -
细胞定位
Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. - Information by UniProt
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数据库链接
- Entrez Gene: 23515 Human
- Omim: 610078 Human
- SwissProt: Q14149 Human
- Unigene: 421150 Human
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别名
- KIAA0136 antibody
- Microrchidia 3 antibody
- MORC family CW type zinc finger 3 antibody
see all
图片
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Anti-MORC3 antibody (ab76813) at 1/500 dilution + nuclear extracts from Hela cells at 25 µg
Secondary
Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/2500 dilution
Predicted band size: 107 kDa
Observed band size: 125 kDa why is the actual band size different from the predicted? -
All lanes : Anti-MORC3 antibody (ab76813) at 1/500 dilution
Lane 1 : MORC3 transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/2500 dilution
Predicted band size: 107 kDa
Observed band size: 125 kDa why is the actual band size different from the predicted?
数据表及文件
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Datasheet download
文献 (2)
ab76813 被引用在 2 文献中.
- Ver LS et al. The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication. J Virol 89:10023-30 (2015). PubMed: 26202233
- Ichimura Y et al. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy. Ann Rheum Dis : (2012). WB ; Human . PubMed: 22258483