Anti-MDC抗体(ab9847)
Key features and details
- Rabbit polyclonal to MDC
- Suitable for: Sandwich ELISA, WB
- Reacts with: Human
- Isotype: unknown
概述
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产品名称
Anti-MDC抗体
参阅全部 MDC 一抗 -
描述
兔多克隆抗体to MDC -
宿主
Rabbit -
经测试应用
适用于: Sandwich ELISA, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human MDC. Highly pure (>98%) recombinant hMDC(human Macrophage-Derived Chemokine)
Database link: O00626 -
阳性对照
- Recombinant human MDC protein (ab9848) can be used as a positive control in WB.
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常规说明
This product is no longer batch tested in IHC, for an IHC validated antibody please see ab124768
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
No preservative, sterile filtered -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
unknown -
轻链类型
unknown -
研究领域
相关产品
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Compatible Secondaries
应用
应用 | Ab评论 | 说明 |
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Sandwich ELISA |
Use a concentration of 0.5 - 2 µg/ml.
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WB |
Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 11 kDa.
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说明 |
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Sandwich ELISA
Use a concentration of 0.5 - 2 µg/ml. |
WB
Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 11 kDa. |
靶标
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功能
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. -
组织特异性
Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. -
序列相似性
Belongs to the intercrine beta (chemokine CC) family. -
翻译后修饰
The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 6367 Human
- Omim: 602957 Human
- SwissProt: O00626 Human
- Unigene: 534347 Human
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别名
- A 152E5.1 antibody
- ABCD 1 antibody
- ABCD1 antibody
see all
数据表及文件
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Datasheet download
文献 (9)
ab9847 被引用在 9 文献中.
- Liang H & Peng J LncRNA HOTAIR promotes proliferation, invasion and migration in NSCLC cells via the CCL22 signaling pathway. PLoS One 17:e0263997 (2022). PubMed: 35176085
- Jiang Z et al. MicroRNA-23a-3p influences the molecular mechanism of gastric cancer cells via CCL22/PI3K/Akt axis. Bioengineered 12:11277-11287 (2021). PubMed: 34874224
- Wang L et al. Anti-CCL22 increases regulatory T cells in CD4+ T cells of rheumatoid arthritis patients via STAT5 pathway. Exp Ther Med 19:2127-2132 (2020). PubMed: 32104275
- Zhang K et al. HBV promotes the recruitment of IL-17 secreting T cells via chemokines CCL22 and CCL17. Liver Int 40:1327-1338 (2020). PubMed: 32187823
- Wu S et al. C-C motif chemokine 22 predicts postoperative prognosis and adjuvant chemotherapeutic benefits in patients with stage II/III gastric cancer. Oncoimmunology 7:e1433517 (2018). PubMed: 29872564
- Liang D et al. Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal. Biochim Biophys Acta 1852:2494-503 (2015). PubMed: 26303640
- Döring C et al. A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma. Mod Pathol N/A:N/A (2014). PubMed: 24633193
- Li YQ et al. Tumor Secretion of CCL22 Activates Intratumoral Treg Infiltration and Is Independent Prognostic Predictor of Breast Cancer. PLoS One 8:e76379 (2013). IHC-P ; Human . PubMed: 24124553
- Qin XJ et al. CCL22 recruits CD4-positive CD25-positive regulatory T cells into malignant pleural effusion. Clin Cancer Res 15:2231-7 (2009). IHC-P ; Human . PubMed: 19318474