LY 344864 hydrochloride,5-HT1F激动剂(ab120592)
Key features and details
- Selective, potent 5-HT1F agonist
- CAS Number: 186544-26-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 5 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
LY 344864 hydrochloride,5-HT1F激动剂 -
描述
Selective,potent 5-HT1F激动剂 -
生物学描述
Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.
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纯度
> 98% -
CAS编号
186544-26-3 -
化学结构
性能
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化学名称
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride -
分子量
387.88 -
分子式
C21H22FN3O.HCl -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in water to 5 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120592 被引用在 1 文献中.
- Stantcheva KK et al. A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression. EMBO Rep 17:585-600 (2016). PubMed: 26929027