概述

性能

应用

Our Abpromise guarantee covers the use of ab21203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 63 kDa).

靶标

  • 功能
    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
  • 组织特异性
    Preferentially expressed by lymphoid cell lines.
  • 疾病相关
    Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
    Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.
  • 序列相似性
    Belongs to the SH2B adapter family.
    Contains 1 PH domain.
    Contains 1 SH2 domain.
  • 翻译后修饰
    Tyrosine phosphorylated by LCK.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IDDM20 antibody
    • Lymphocyte adapter protein antibody
    • Lymphocyte specific adapter protein antibody
    • Lymphocyte specific adapter protein Lnk antibody
    • Lymphocyte-specific adapter protein Lnk antibody
    • SH2B adapter protein 3 antibody
    • SH2B adaptor protein 3 antibody
    • Sh2b3 antibody
    • SH2B3_HUMAN antibody
    • Signal transduction protein Lnk antibody
    see all

图片

实验方案

文献

This product has been referenced in:
  • Takizawa H  et al. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120:179-90 (2010). Read more (PubMed: 20038804) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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