Anti-KIF7抗体(ab95884)
Key features and details
- Rabbit polyclonal to KIF7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-KIF7抗体 -
描述
兔多克隆抗体to KIF7 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rhesus monkey, Gorilla, Orangutan -
免疫原
Synthetic peptide corresponding to Human KIF7 aa 1200-1300.
Database link: Q2M1P5 -
阳性对照
- HeLa or 293T cell lysate
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常规说明
Shelf Life: 1 year from date of receiptThe Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. The product can be stored for up to 12 months. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95884于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (1) |
1/2000 - 1/10000. Predicted molecular weight: 151 kDa.
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说明 |
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WB
1/2000 - 1/10000. Predicted molecular weight: 151 kDa. |
靶标
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功能
Acts as both a negative and positive regulator of sonic hedgehog (Shh) pathway, acting downstream of SMO. Negatively regulates the pathway by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. Required for efficient localization of GLI3 to cilia in response to Shh. May also act as a ciliary motor. -
组织特异性
Embryonic stem cells, melanotic melanoma and Jurkat T-cells. -
序列相似性
Belongs to the kinesin-like protein family. KIF27 subfamily.
Contains 1 kinesin-motor domain. -
细胞定位
Cell projection > cilium. SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway. - Information by UniProt
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数据库链接
- Entrez Gene: 374654 Human
- Omim: 611254 Human
- SwissProt: Q2M1P5 Human
- Unigene: 513134 Human
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别名
- EQYK340 antibody
- kif7 antibody
- KIF7_HUMAN antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab95884 被引用在 2 文献中.
- Massa F et al. The deubiquitinating enzyme USP14 controls ciliogenesis and hedgehog signalling. Hum Mol Genet N/A:N/A (2018). PubMed: 30388222
- Ho J et al. Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells. PLoS One 9:e108248 (2014). WB ; Human . PubMed: 25265279