Anti-Interferon gamma抗体[XMG1.2] (ab23637)
Key features and details
- Rat monoclonal [XMG1.2] to Interferon gamma
- Suitable for: ELISA, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
Related conjugates and formulations
概述
-
产品名称
Anti-Interferon gamma抗体[XMG1.2]
参阅全部 Interferon gamma 一抗 -
描述
大鼠单克隆抗体[XMG1.2] to Interferon gamma -
宿主
Rat -
经测试应用
适用于: ELISA, Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant full length protein corresponding to Mouse Interferon gamma.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
-
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
XMG1.2 -
同种型
IgG1 -
研究领域
相关产品
-
Alternative Versions
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23637于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ELISA | ||
Flow Cyt |
说明 |
---|
Flow Cyt: Membrane permeablisation is required for this application. Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
-
功能
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. -
组织特异性
Released primarily from activated T lymphocytes. -
疾病相关
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. -
序列相似性
Belongs to the type II (or gamma) interferon family. -
翻译后修饰
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. -
细胞定位
Secreted. - Information by UniProt
-
数据库链接
- Entrez Gene: 15978 Mouse
- SwissProt: P01580 Mouse
- Unigene: 240327 Mouse
-
别名
- IF 1 antibody
- IFG antibody
- IFI antibody
see all
数据表及文件
-
SDS download
-
Datasheet download
文献 (3)
ab23637 被引用在 3 文献中.
- Zhou Y et al. MicroRNA-29a induces insulin resistance by targeting PPARd in skeletal muscle cells. Int J Mol Med 37:931-8 (2016). WB ; Rat . PubMed: 26936652
- Hsieh B et al. In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J Immunol 156:232-7 (1996). PubMed: 8598467
- Cherwinski HM et al. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 166:1229-44 (1987). PubMed: 2960769