Anti-Integrin alpha 3b抗体[54B3] (ab8988)
Key features and details
- Mouse monoclonal [54B3] to Integrin alpha 3b
- Suitable for: ICC, WB, IHC-Fr
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Integrin alpha 3b抗体[54B3] -
描述
小鼠单克隆抗体[54B3] to Integrin alpha 3b -
宿主
Mouse -
特异性
Recognizes specifically the cytoplasmic domain of integrin subunit a3B which is present in microvascular structures in brain and heart. -
经测试应用
适用于: ICC, WB, IHC-Frmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Integrin alpha 3b conjugated to keyhole limpet haemocyanin.
Database link: P26006 -
表位
Cytoplasmic domain of a3B Integrin. -
常规说明
The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
Primary antibody说明
The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix. -
克隆
单克隆 -
克隆编号
54B3 -
骨髓瘤
Sp2/0 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
应用 | Ab评论 | 说明 |
---|---|---|
ICC |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
|
|
IHC-Fr |
Use at an assay dependent concentration.
|
说明 |
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ICC
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
靶标
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相关性
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. -
细胞定位
Cell Membrane -
数据库链接
- Entrez Gene: 3675 Human
- SwissProt: P26006 Human
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别名
- CD49C antibody
- GAPB3 antibody
- Integrin alpha-3 heavy chain antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (6)
ab8988 被引用在 6 文献中.
- Parsegian A et al. Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes. Front Psychiatry 13:1024617 (2022). PubMed: 36311521
- Khalkar P et al. Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis. Free Radic Biol Med 117:247-257 (2018). WB ; Human . PubMed: 29438720
- Tobiasson M et al. Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease. Oncotarget 8:28812-28825 (2017). PubMed: 28427179
- Zhang K et al. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol 383:15-27 (2013). PubMed: 24036311
- Ipenberg I et al. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem 288:14681-7 (2013). PubMed: 23589305
- Kim A et al. Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol 27:1271-9 (2007). PubMed: 17158930