Anti-IL-23抗体[G23-8] (ab91271)
Key features and details
- Rat monoclonal [G23-8] to IL-23
- Suitable for: WB, Functional Studies, ELISA
- Reacts with: Mouse
- Isotype: IgG1
概述
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产品名称
Anti-IL-23抗体[G23-8]
参阅全部 IL-23 一抗 -
描述
大鼠单克隆抗体[G23-8] to IL-23 -
宿主
Rat -
特异性
ab91271 reacts with the p19 subunit of IL23. -
经测试应用
适用于: WB, Functional Studies, ELISAmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant fragment corresponding to IL-23.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: PBS, 0.87% Sodium chloride -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
ab91271 is affinity purified. -
克隆
单克隆 -
克隆编号
G23-8 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab91271于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use at an assay dependent concentration.
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Neutralization |
Use at an assay dependent concentration.
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Functional Studies |
Use at an assay dependent concentration.
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ELISA |
Use a concentration of 1 - 4 µg/ml.
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说明 |
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WB
Use at an assay dependent concentration. |
Neutralization
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. |
ELISA
Use a concentration of 1 - 4 µg/ml. |
靶标
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功能
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. -
组织特异性
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). -
序列相似性
Belongs to the IL-6 superfamily. -
发展阶段
Expressed by newborns dendritic cells. -
细胞定位
Secreted. Secreted upon association with IL12B. - Information by UniProt
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数据库链接
- Entrez Gene: 16160 Mouse
- Entrez Gene: 83430 Mouse
- SwissProt: P43432 Mouse
- SwissProt: Q9EQ14 Mouse
- Unigene: 125482 Mouse
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别名
- IL 23 A antibody
- IL 23 antibody
- IL 23 subunit alpha antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab91271 被引用在 1 文献中.
- Ivanov S et al. Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am J Respir Cell Mol Biol 36:442-51 (2007). WB . PubMed: 17142310