Anti-IL-23抗体[B-Z23] - BSA and Azide free (ab84471)
Key features and details
- Mouse monoclonal [B-Z23] to IL-23 - BSA and Azide free
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-IL-23抗体[B-Z23] - BSA and Azide free
参阅全部 IL-23 一抗 -
描述
小鼠单克隆抗体[B-Z23] to IL-23 - BSA and Azide free -
宿主
Mouse -
特异性
Recognizes both recombinant and natural human IL23, p19 sub-unit.
Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production).
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经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human IL-23.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Constituent: 100% PBS
Sterile-filtered through 0.22 µm. Carrier and preservative free -
无载体
是 -
Concentration information loading...
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纯度
Ion Exchange Chromatography -
纯化说明
Sterile-filtered through 0.22 µm and treated to remove endotoxins. -
克隆
单克隆 -
克隆编号
B-Z23 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab84471于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/500.
|
说明 |
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IHC-P
1/500. |
靶标
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功能
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. -
组织特异性
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). -
序列相似性
Belongs to the IL-6 superfamily. -
发展阶段
Expressed by newborns dendritic cells. -
细胞定位
Secreted. Secreted upon association with IL12B. - Information by UniProt
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数据库链接
- Entrez Gene: 3593 Human
- Entrez Gene: 51561 Human
- Omim: 161561 Human
- Omim: 605580 Human
- SwissProt: P29460 Human
- SwissProt: Q9NPF7 Human
- Unigene: 382212 Human
- Unigene: 98309 Human
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别名
- IL 23 A antibody
- IL 23 antibody
- IL 23 subunit alpha antibody
see all
图片
数据表及文件
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Datasheet download
文献 (2)
ab84471 被引用在 2 文献中.
- Ziblat A et al. Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation. Front Immunol 8:1959 (2017). PubMed: 29403472
- Zhang L et al. IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway. Carcinogenesis 35:1330-40 (2014). PubMed: 24464786