人BDNF多肽(ab182199)
Key features and details
- Suitable for: Blocking
描述
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产品名称
人BDNF多肽
参阅全部 BDNF 蛋白酶 -
Accession
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无动物成分
No -
性质
Synthetic -
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种属
Human
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相关产品
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Corresponding Antibody
技术指标
Our Abpromise guarantee covers the use of ab182199 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Blocking - Blocking peptide for Anti-BDNF antibody [EPR1292] (ab108319)
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形式
Lyophilized -
补充说明
This is the blocking peptide for ab108319
- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
- If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use. -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term.
Information available upon request.
常规信息
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别名
- Abrineurin
- ANON2
- BDNF
see all -
功能
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. -
组织特异性
Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. -
疾病相关
Bulimia nervosa 2
Congenital central hypoventilation syndrome -
序列相似性
Belongs to the NGF-beta family. -
翻译后修饰
The propeptide is N-glycosylated and glycosulfated.
Converted into mature BDNF by plasmin (PLG). -
细胞定位
Secreted. - Information by UniProt
图片
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To learn more about our protein and peptide range click here.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (3)
ab182199 被引用在 3 文献中.
- Lee HW et al. Effects of exercise on BDNF-TrkB signaling in the paraventricular nucleus and rostral ventrolateral medulla in rats post myocardial infarction. Neuropeptides N/A:102058 (2020). PubMed: 32507324
- Ma Z et al. Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors. Cell Death Dis 11:834 (2020). PubMed: 33033239
- Matsuzaka Y et al. The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice. BMC Med 18:343 (2020). PubMed: 33208172