Anti-Hrk抗体(ab45419)
Key features and details
- Rabbit polyclonal to Hrk
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-Hrk抗体 -
描述
兔多克隆抗体to Hrk -
宿主
Rabbit -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide of 15 amino acids in length from near the center of human Hrk
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阳性对照
- Mouse pancreas tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab45419于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
Use at an assay dependent concentration.
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WB | (1) |
Use a concentration of 2.5 - 5 µg/ml. Detects a band of approximately 13 kDa (predicted molecular weight: 10 kDa).
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说明 |
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ICC/IF
Use at an assay dependent concentration. |
WB
Use a concentration of 2.5 - 5 µg/ml. Detects a band of approximately 13 kDa (predicted molecular weight: 10 kDa). |
靶标
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功能
Promotes apoptosis. -
结构域
The BH3 motif is required for the induction of cell death. -
细胞定位
Membrane. Mitochondrion. - Information by UniProt
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数据库链接
- Entrez Gene: 8739 Human
- Entrez Gene: 12123 Mouse
- Omim: 603447 Human
- SwissProt: O00198 Human
- SwissProt: P62816 Mouse
- Unigene: 87247 Human
- Unigene: 384468 Mouse
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别名
- Activator of apoptosis harakiri antibody
- Activator of apoptosis Hrk antibody
- BCL2 interacting protein antibody
see all
图片
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Lane 1 : Anti-Hrk antibody (ab45419) at 2.5 µg/ml
Lane 2 : Anti-Hrk antibody (ab45419) at 5 µg/ml
All lanes : Mouse pancreas tissue lysate
Predicted band size: 10 kDa
Observed band size: 13 kDa why is the actual band size different from the predicted?
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab45419 被引用在 5 文献中.
- Dunn S et al. AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors. Oncogene 41:5046-5060 (2022). PubMed: 36241868
- Liang R et al. The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Cancers (Basel) 13:N/A (2021). PubMed: 34572804
- Duval N et al. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Front Cell Neurosci 12:15 (2018). WB ; Mouse . PubMed: 29440992
- Li D et al. Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4. Nat Commun 9:2829 (2018). PubMed: 30026490
- Wang NN et al. Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int J Mol Sci 16:1266-92 (2015). PubMed: 25574601