Anti-HIV1 gp120抗体(ab21179)
Key features and details
- Goat polyclonal to HIV1 gp120
- Suitable for: ELISA, WB
- Reacts with: Human immunodeficiency virus
- Isotype: IgG
概述
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产品名称
Anti-HIV1 gp120抗体
参阅全部 HIV1 gp120 一抗 -
描述
山羊多克隆抗体to HIV1 gp120 -
宿主
Goat -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Human immunodeficiency virus -
免疫原
Purified native gp120 from strain IIIB.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading...
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纯化说明
Purified by Sodium sulfate precipitation and ion-exchange chromatography.>95% pure. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab21179于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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WB | (1) |
1/1000. Predicted molecular weight: 120 kDa. Dilution optimised using Chromogenic detection
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说明 |
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ELISA
Use at an assay dependent concentration. |
WB
1/1000. Predicted molecular weight: 120 kDa. Dilution optimised using Chromogenic detection |
靶标
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相关性
HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response. -
细胞定位
Envelope surface glycoprotein. -
数据库链接
- Entrez Gene: 155971 Human immunodeficiency virus
- GenBank: AAG28611 Human immunodeficiency virus
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别名
- Glycoprotein 120 antibody
- gp120 antibody
- SU antibody
- Surface protein antibody
数据表及文件
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SDS download
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Datasheet download
文献 (24)
ab21179 被引用在 24 文献中.
- Mao D et al. TMEM106A inhibits enveloped virus release from cell surface. iScience 25:103843 (2022). PubMed: 35198896
- Imamichi H et al. Defective HIV-1 proviruses produce viral proteins. Proc Natl Acad Sci U S A 117:3704-3710 (2020). PubMed: 32029589
- Liu Y et al. PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins. Cell Discov 6:53 (2020). PubMed: 32802403
- Zhang Y et al. MARCH8 inhibits viral infection by two different mechanisms. Elife 9:N/A (2020). PubMed: 32778221
- Giel-Moloney M et al. Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector. Sci Rep 9:20005 (2019). PubMed: 31882800