GsMTx-4,mechanosensitive and stretch-activated ion channel抑制剂(ab141871)
Key features and details
- Mechanosensitive and stretch-activated ion channel inhibitor
- CAS Number: 1209500-46-8
Soluble in water to 1mg/ml
- Form / State: Solid
- Source: Grammostola rosea
概述
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产品名称
GsMTx-4,mechanosensitive and stretch-activated ion channel抑制剂 -
描述
Mechanosensitive and stretch-activated ion channel抑制剂 -
CAS编号
1209500-46-8 -
化学结构
性能
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分子量
4095.85 -
分子式
C185H273N49O45S6 -
序列
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)
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PubChem识别号
90488987 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 1mg/ml
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处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Grammostola rosea
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研究领域
图片
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2D chemical structure image of ab141871, GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
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GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (29)
ab141871 被引用在 29 文献中.
- Shen X et al. A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement. Aust Endod J 49 Suppl 1:228-237 (2023). PubMed: 36461169
- Luo M et al. Chemical Activation of Piezo1 Alters Biomechanical Behaviors toward Relaxation of Cultured Airway Smooth Muscle Cells. Biol Pharm Bull 46:1-11 (2023). PubMed: 36596517
- Gonçalves AN et al. Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2. Respir Res 24:42 (2023). PubMed: 36740669
- Zhu T et al. The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia. iScience 26:105993 (2023). PubMed: 36798430
- Lopez-Cavestany M et al. Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells. iScience 26:106275 (2023). PubMed: 36950111