Anti-Glutamate Transporter 1抗体(ab106289)
Key features and details
- Rabbit polyclonal to Glutamate Transporter 1
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Glutamate Transporter 1抗体 -
描述
兔多克隆抗体to Glutamate Transporter 1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat
预测可用于: Human -
免疫原
Synthetic peptide corresponding to Rat Glutamate Transporter 1 (C terminal). A 16 residue synthetic peptide derived from the C terminal domain of Rat glutamate transporter 1.
Database link: P31596 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Avoid freeze / thaw cycle. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106289于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/200 - 1/5000. Predicted molecular weight: 62 kDa.
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说明 |
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WB
1/200 - 1/5000. Predicted molecular weight: 62 kDa. |
靶标
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功能
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. -
序列相似性
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. -
翻译后修饰
Glycosylated.
Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6506 Human
- Entrez Gene: 20511 Mouse
- Entrez Gene: 29482 Rat
- Omim: 600300 Human
- SwissProt: P43004 Human
- SwissProt: P43006 Mouse
- SwissProt: P31596 Rat
- Unigene: 502338 Human
see all -
别名
- EAA2_HUMAN antibody
- EAAT2 antibody
- Excitatory amino acid transporter 2 antibody
see all
图片
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All lanes : Anti-Glutamate Transporter 1 antibody (ab106289) at 1/1000 dilution
Lane 1 : Protein extract from rat brain
Lane 2 : Protein extract from mouse brain
Predicted band size: 62 kDa
Lane 3 shows inhibition of the immunoreactivity of ab106289 with blocking peptide.
Glutamate Transporter 1 protein is detected at 35 kDa and 70 kDa as a dimer.
数据表及文件
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Datasheet download
文献 (11)
ab106289 被引用在 11 文献中.
- Postnikova TY et al. Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats. Int J Mol Sci 23:N/A (2022). PubMed: 36362260
- Sanches E et al. Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain. Nutrients 13:N/A (2021). PubMed: 34836132
- Yan M et al. Ginkgo biloba extract protects diabetic rats against cerebral ischemia-reperfusion injury by suppressing oxidative stress and upregulating the expression of glutamate transporter 1. Mol Med Rep 21:1809-1818 (2020). PubMed: 32319622
- Lu Y et al. Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain. J Neurosci 40:7355-7374 (2020). PubMed: 32817249
- Wang J et al. Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury. J Neurosci 40:9751-9771 (2020). PubMed: 33158962