Anti-GTF2IRD1抗体(ab64805)
Key features and details
- Rabbit polyclonal to GTF2IRD1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-GTF2IRD1抗体 -
描述
兔多克隆抗体to GTF2IRD1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
A synthetic peptide derived from N terminus of human GTF2IRD1.
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阳性对照
- Extracts from 293 cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab64805于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa). |
靶标
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功能
May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8. -
组织特异性
Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested. -
疾病相关
Note=GTF2IRD1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2IRD1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. -
序列相似性
Belongs to the TFII-I family.
Contains 5 GTF2I-like repeats. -
发展阶段
Highly expressed in developing and regenerating muscles, at the time of myofiber diversification. -
结构域
The N-terminal half may have an activating activity. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 9569 Human
- Entrez Gene: 57080 Mouse
- Entrez Gene: 246770 Rat
- Omim: 604318 Human
- SwissProt: Q6DSU6 Human
- SwissProt: Q9UHL9 Human
- SwissProt: Q9JI57 Mouse
- Unigene: 647056 Human
see all -
别名
- CREAM1 antibody
- General transcription factor II I repeat domain containing protein 1 antibody
- General transcription factor II-I repeat domain-containing protein 1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab64805 被引用在 1 文献中.
- Masuda T et al. The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. J Neurosci 34:15356-68 (2014). WB, IP, IHC ; Mouse . PubMed: 25392503