Anti-FREM1抗体(ab105360)
Key features and details
- Rabbit polyclonal to FREM1
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FREM1抗体
参阅全部 FREM1 一抗 -
描述
兔多克隆抗体to FREM1 -
宿主
Rabbit -
特异性
ab105360 is predicted to not crossreact with other FRAS members. Multiple isoforms are known to exist. -
经测试应用
适用于: WB, ICCmore details -
种属反应性
与反应: Human -
免疫原
A 15 amino acid peptide near the C terminus of Human FREM1 (NP_659403).
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阳性对照
- K562 cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105360于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.5 - 1 µg/ml.
Predciated Band: 244 for isoform 1 , for isoform 2 (TILRR), 80 kDa |
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ICC |
Use a concentration of 20 µg/ml.
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说明 |
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WB
Use a concentration of 0.5 - 1 µg/ml. Predciated Band: 244 for isoform 1 , for isoform 2 (TILRR), 80 kDa |
ICC
Use a concentration of 20 µg/ml. |
靶标
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功能
Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. -
疾病相关
Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations. -
序列相似性
Belongs to the FRAS1 family.
Contains 1 C-type lectin domain.
Contains 1 Calx-beta domain.
Contains 12 CSPG (NG2) repeats. -
结构域
The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding. -
细胞定位
Secreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles. - Information by UniProt
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数据库链接
- Entrez Gene: 158326 Human
- Omim: 608944 Human
- SwissProt: Q5H8C1 Human
- Unigene: 50850 Human
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别名
- BC037594 antibody
- BNAR antibody
- C9orf143 antibody
see all
图片
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Immunofluorescence of FREM1 in K562 cells with ab105360 at 20 ug/mL.
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Lane 1 : Anti-FREM1 antibody (ab105360) at 1 µg/ml
Lane 2 : Anti-FREM1 antibody (ab105360) at 0.5 µg/ml
All lanes : K562 cell lysate
Lysates/proteins at 15 µg per lane.Predicted band size: 244 for isoform 1 , for isoform 2 (TILRR), 80 kDa
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Immunocytochemistry of FREM1 in K562 cells with ab105360 at 20 µg/ml.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab105360 被引用在 1 文献中.
- Wang X et al. TILRR Aggravates Sepsis-Induced Acute Lung Injury by Suppressing the PI3K/Akt Pathway. Evid Based Complement Alternat Med 2022:7341504 (2022). PubMed: 36065264