Etomidate,GABAA激动剂(ab120311)
Key features and details
- GABAA agonist
- CAS Number: 33125-97-2
- Soluble in DMSO to 100 mM, in ethanol to 500 mM, in 1 eq. HCl to 100 mM (with heating) and in water to 1 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Etomidate,GABAA激动剂 -
描述
GABAA激动剂 -
生物学描述
Agonist at GABAA receptors containing β3 subunits. Anaesthetic and amnesic properties.
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CAS编号
33125-97-2 -
化学结构
性能
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化学名称
Ethyl 1-((R)-1-phenylethyl)-1H-imidazole-5-carboxylate -
分子量
244.29 -
分子式
C14H16N2O2 -
PubChem识别号
667484 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM, in ethanol to 500 mM, in 1 eq. HCl to 100 mM (with heating) and in water to 1 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](c1ccccc1)n2cncc2C(=O)OCC -
来源
Synthetic
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研究领域
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120311于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Functional Studies |
Use at an assay dependent concentration.
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说明 |
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Functional Studies
Use at an assay dependent concentration. |
图片
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2D chemical structure image of ab120311, Etomidate, GABAA agonist
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ab7977 staining BAX in RAW 264.7 cells treated with etomidate (ab120311), by ICC/IF. Increase in BAX expression correlates with increased concentration of etomidate, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120311 (etomidate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab120311 尚未被引用在任何文献中。