重组Anti-ErbB3 / HER3抗体[SP71],prediluted (ab101544)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP71] to ErbB3 / HER3, prediluted
- Suitable for: IHC-P
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-ErbB3 / HER3抗体[SP71],prediluted
参阅全部 ErbB3 / HER3 一抗 -
描述
兔单克隆抗体[SP71] to ErbB3 / HER3,prediluted -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human ErbB3/ HER3 aa 650-750 (internal sequence). The exact sequence is proprietary.
Database link: P21860 -
表位
Internal region -
阳性对照
- Human small intestine
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常规说明
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: Tris buffered saline, 1% BSA -
Concentration information loading...
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纯度
Protein A/G purified -
纯化说明
Purified from TCS by protein A/G. -
克隆
单克隆 -
克隆编号
SP71 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
- Anti-ErbB3 / HER3 antibody [SP71] - BSA and Azide free (ab236220)
- Alexa Fluor® 488 Anti-ErbB 3 antibody [SP71] (ab309933)
- Alexa Fluor® 647 Anti-ErbB 3 antibody [SP71] (ab310300)
- Alexa Fluor® 594 Anti-ErbB 3 antibody [SP71] (ab310763)
- Alexa Fluor® 555 Anti-ErbB 3 antibody [SP71] (ab312290)
- Alexa Fluor® 568 Anti-ErbB3 / HER3 antibody [SP71] (ab312785)
- Anti-ErbB3 / HER3 antibody [SP71] (ab93739)
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab101544于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/1. (Prediluted). Antigen Retrieval: boil tissue section in 1mM EDTA, pH 8.0 for 10 minutes followed by cooling at room temperature for 20 minutes.
|
说明 |
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IHC-P
1/1. (Prediluted). Antigen Retrieval: boil tissue section in 1mM EDTA, pH 8.0 for 10 minutes followed by cooling at room temperature for 20 minutes. |
靶标
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功能
Binds and is activated by neuregulins and NTAK. -
组织特异性
Epithelial tissues and brain. -
疾病相关
Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Contains 1 protein kinase domain. -
发展阶段
Overexpressed in a subset of human mammary tumors. -
结构域
The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. -
翻译后修饰
Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2065 Human
- Omim: 190151 Human
- SwissProt: P21860 Human
- Unigene: 118681 Human
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别名
- c erbB 3 antibody
- c erbB3 antibody
- Erb b2 receptor tyrosine kinase 3 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab101544 被引用在 1 文献中.
- Huang J et al. The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells. Mol Cancer 12:134 (2013). PubMed: 24215614