Anti-Dact2抗体(ab79042)
Key features and details
- Rabbit polyclonal to Dact2
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Dact2抗体 -
描述
兔多克隆抗体to Dact2 -
宿主
Rabbit -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
A 12 amino acid synthetic peptide from near the amino terminus of human Dact2 (NP_999627).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab79042于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa.
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ICC/IF |
Use a concentration of 20 µg/ml.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa. |
ICC/IF
Use a concentration of 20 µg/ml. |
靶标
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功能
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. -
序列相似性
Belongs to the dapper family. -
结构域
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins. - Information by UniProt
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数据库链接
- Entrez Gene: 168002 Human
- Omim: 608966 Human
- SwissProt: Q5SW24 Human
- Unigene: 673059 Human
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别名
- bA503C24.7 antibody
- C6orf116 antibody
- Chromosome 6 open reading frame 116 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab79042 被引用在 4 文献中.
- Wang Y et al. miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis. Mol Ther Nucleic Acids 24:610-621 (2021). PubMed: 33898109
- Guo L et al. Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway. Oncol Lett 15:3287-3294 (2018). PubMed: 29435071
- Guo YL et al. Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. J Biomed Sci 24:6 (2017). IHC-P ; Human . PubMed: 28077137
- Hou J et al. DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma. Cancer Prev Res (Phila) 6:791-800 (2013). PubMed: 23803417