Anti-Collagen III抗体[1E7-D7/Col3] (ab23445)
Key features and details
- Mouse monoclonal [1E7-D7/Col3] to Collagen III
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
-
产品名称
Anti-Collagen III抗体[1E7-D7/Col3]
参阅全部 Collagen III 一抗 -
描述
小鼠单克隆抗体[1E7-D7/Col3] to Collagen III -
宿主
Mouse -
特异性
ab23445 is highly specific for type III Collagen. It has been shown to have no cross reactivity with type I and V Collagens. There is no evidence for cross reactivity with other connective tissue proteins (laminin, fibronectin, elastin). -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
不与反应: Sheep, Cow -
免疫原
Full length native protein (purified) corresponding to Human Collagen III.
Database link: P02461 -
表位
The epitope recognised by ab23445 is located approximately 100nm from the N terminal of the molecule. -
阳性对照
- Frozen and unfixed human or kangaroo skin tissue slides.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
-
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
1E7-D7/Col3 -
骨髓瘤
NS1/1-Ag4-1 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23445于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P | (2) |
Use at an assay dependent concentration.
|
说明 |
---|
IHC-P
Use at an assay dependent concentration. |
靶标
-
功能
Collagen type III occurs in most soft connective tissues along with type I collagen. -
疾病相关
Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.
Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. -
序列相似性
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 VWFC domain. -
翻译后修饰
Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group. -
细胞定位
Secreted > extracellular space > extracellular matrix. - Information by UniProt
-
数据库链接
- Entrez Gene: 1281 Human
- Omim: 120180 Human
- SwissProt: P02461 Human
- Unigene: 443625 Human
-
别名
- Alpha 1 type III collagen antibody
- Alpha1 (III) collagen antibody
- CO3A1_HUMAN antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (22)
ab23445 被引用在 22 文献中.
- Wei S et al. Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs. Mil Med Res 8:18 (2021). PubMed: 33685528
- Huang S et al. Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. Aging (Albany NY) 13:4409-4427 (2021). PubMed: 33495414
- Chen J et al. Pathological changes of frozen shoulder in rat model and the therapeutic effect of PPAR-γ agonist. J Orthop Res 39:891-901 (2021). PubMed: 33222263
- Li Y et al. Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis. Stem Cell Res Ther 12:221 (2021). PubMed: 33789737
- Li P et al. Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI. Exp Ther Med 22:1255 (2021). PubMed: 34603523