FITC荧光Anti-CTLA4抗体[1B8] (ab24935)
Key features and details
- FITC Armenian hamster monoclonal [1B8] to CTLA4
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
概述
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产品名称
FITC荧光Anti-CTLA4抗体[1B8]
参阅全部 CTLA4 一抗 -
描述
FITC荧光亚美尼亚仓鼠单克隆抗体[1B8] to CTLA4 -
宿主
Armenian hamster -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
ab24935 recognises mouse CD152/CTLA-4 -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Full length native protein (purified) corresponding to CTLA4. Extracellular portion of murine CTLA-4 fused to a murine IgG2a
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Store In the Dark. -
存储溶液
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Affinity purified -
克隆
单克隆 -
克隆编号
1B8 -
同种型
IgG -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab24935于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use 3µg for 106 cells.
ab18473 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use 3µg for 106 cells. ab18473 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. -
组织特异性
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. -
疾病相关
Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12) [MIM:601388]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3) [MIM:609755]. It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰
N-glycosylation is important for dimerization.
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. -
细胞定位
Cell membrane. Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation and. - Information by UniProt
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数据库链接
- Entrez Gene: 100505288 Mouse
- Entrez Gene: 12477 Mouse
- SwissProt: P09793 Mouse
- Unigene: 390 Mouse
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别名
- ALPS5 antibody
- CD 152 antibody
- CD antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab24935 被引用在 2 文献中.
- Zhou Y et al. MicroRNA-30a controls the instability of inducible CD4+ Tregs through SOCS1. Mol Med Rep 20:4303-4314 (2019). PubMed: 31545427
- Wang W et al. PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells. Int Immunol 21:1065-77 (2009). PubMed: 19651643