Anti-CHL1抗体(ab106269)
Key features and details
- Rabbit polyclonal to CHL1
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CHL1抗体 -
描述
兔多克隆抗体to CHL1 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to amino acids 788-1025 of Human CHL1, accession number NM_006614.
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阳性对照
- HL60 and Jurkat cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106269于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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WB |
1/1000 - 1/2000. Detects a band of approximately 135 kDa (predicted molecular weight: 137 kDa).
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说明 |
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IHC-P
Use at an assay dependent concentration. |
WB
1/1000 - 1/2000. Detects a band of approximately 135 kDa (predicted molecular weight: 137 kDa). |
靶标
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相关性
CHL1 is an extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. CHL1 plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. CHL1 may play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins and recruits ANK3 to the plasma membrane. -
细胞定位
Cell Membrane and Secreted -
数据库链接
- Entrez Gene: 10752 Human
- Entrez Gene: 12661 Mouse
- Entrez Gene: 89828 Rat
- Omim: 607416 Human
- SwissProt: O00533 Human
- SwissProt: P70232 Mouse
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别名
- CALL antibody
- Cell adhesion molecule with homology to L1CAM (close homolog of L1) antibody
- Cell adhesion molecule with homology to L1CAM (close homologue of L1) antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab106269 被引用在 6 文献中.
- Roşianu F et al. Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration. Life Sci Alliance 6:N/A (2023). PubMed: 36446521
- Chen P et al. Identification of NFASC and CHL1 as Two Novel Hub Genes in Endometriosis Using Integrated Bioinformatic Analysis and Experimental Verification. Pharmgenomics Pers Med 15:377-392 (2022). PubMed: 35496348
- Shi Y et al. Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer. J Cell Biochem 121:2655-2663 (2020). PubMed: 31736153
- Zhang C et al. Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis. Eur J Obstet Gynecol Reprod Biol 236:177-182 (2019). PubMed: 30943448
- Valko PO et al. In search of cerebrospinal fluid biomarkers of fatigue in multiple sclerosis: A proteomics study. J Sleep Res N/A:e12721 (2018). PubMed: 29961995
- Martín-Sánchez E et al. CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer. Oncotarget N/A:N/A (2017). PubMed: 28178655