CGP 55845 hydrochloride,GABAB拮抗剂(ab120337)
Key features and details
- Potent, selective GABAB antagonist
- CAS Number: 149184-22-5
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
CGP 55845 hydrochloride,GABAB拮抗剂 -
描述
Potent,selective GABAB拮抗剂 -
别名
- CGP55845 hydrochloride
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CAS编号
149184-22-5 -
化学结构
性能
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化学名称
[(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride -
分子量
438.72 -
分子式
C18H22Cl2NO3P.HCl -
PubChem识别号
9954841 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl -
来源
Synthetic
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研究领域
图片
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2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist
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5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.
(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (31)
ab120337 被引用在 31 文献中.
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Dai KZ et al. Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward. Cell Rep 40:111440 (2022). PubMed: 36170833
- Zhang J et al. Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice. Cell Rep 36:109495 (2021). PubMed: 34348148
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Chittajallu R et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194